Fossi in te userei la versione portable e free di CCleaner
https://www.ccleaner.com/ccleaner/download/portable aggiungendo il file Winapp2.ini delle configurazioni software reperibile all'indirizzo...
http://www.winapp2.com/downloads.html
Se comunque vuoi farlo manualmente cerca il riferimento nel file Winapp2.ini e troverai questo...
[Windows Defender *]
LangSecRef=3024
Detect=HKLM\Software\Microsoft\Windows Defender
Default=False
FileKey1=%CommonAppData%\Microsoft\Windows Defender\Network Inspection System\Support|*.txt
FileKey2=%CommonAppData%\Microsoft\Windows Defender\Scans|*.bin;*.bin*
FileKey3=%CommonAppData%\Microsoft\Windows Defender\Scans\History\CacheManager|*.*|RECURSE
FileKey4=%CommonAppData%\Microsoft\Windows Defender\Scans\History\ReportLatency\Latency|*.*|R ECURSE
FileKey5=%CommonAppData%\Microsoft\Windows Defender\Scans\History\Service|*.log
FileKey6=%CommonAppData%\Microsoft\Windows Defender\Scans\MetaStore|*.*|RECURSE
FileKey7=%CommonAppData%\Microsoft\Windows Defender\Support|*.*|RECURSE